Cristiano Ronaldo has tested positive for coronavirus.
The Juventus star is feeling well and has not been shown any symptoms.
The striker is is now self-isolating and will play no part in Portugal’s clash with Sweden.
The rest of the Portugal team have returned negative tests and are available for selection.
Portugal’s Football Federation through a statement said: “Cristiano Ronaldo was released from the work of the National Team after a positive test for COVID-19, so he will not face Sweden.
“The Portuguese international is doing well, without symptoms, and in isolation.
“Following the positive case, the remaining players underwent new tests this Tuesday morning, all with a negative result, and are available to Fernando Santos for training this afternoon, in the City of Football.
“The game, counting for the qualification phase of the League of Nations, is scheduled for Wednesday, at 19:45, in Alvalade.”
Portugal will play Sweden in the Nations League on Wednesday night.
The 35 year old Ronaldo played the full 90 minutes of Portugal’s goalless draw with France in Paris on Sunday.
The Juventus forward also played against Spain in Lisbon last Thursday.
In September, Ronaldo became the first European player to reach 100 international goals after scoring twice in Portugal’s 2-0 win.
Ronaldo has set his sights on Iranian Ali Daei’s record for a male international of 109 goals.