Real Madrid suffered a shock 1-0 home loss to promoted Cadiz while Barcelona were beaten by the same scoreline at Getafe, who moved into second place in LaLiga.
Real head coach Zinedine Zidane offered no excuses as the reigning champions slumped to a first ever loss against Cadiz.
Anthony Lozano’s first-half goal proved enough for an unlikely win for the newcomers, who held off a second-half onslaught at the Estadio Alfredo Di Stefano with Karim Benzema’s late effort crashing off the crossbar.
Barcelona, though, failed to capitalise as a penalty from Jaime Mata after 56 minutes settled matters at the Coliseum Alfonso Perez.
Lionel Messi had struck a post during the first half, but it was a frustrating evening for the Catalans as Getafe, who also hit the woodwork during the closing stages, went level on points with leaders Madrid.
Barca’s first defeat of the season under head coach Ronald Koeman leaves them ninth in the table, three points adrift, but still with a game in hand.
Luis Suarez’s early goal set Atletico Madrid on their way to a 2-0 win at Celta Vigo, with substitute Yannick Carrasco adding a second in stoppage time.
Granada beat Sevilla 1-0 with a late goal from Yangel Herrera after the visitors had seen midfielder Joan Jordan Moreno sent off just before half-time.